The chemistry of marine natural products has grown enormously in the last fifty years. On land, communication between insects is largely by pheromones. Because these must be volatile, their chemical structures are often simple and many are easy to synthesize. In contrast, in an aqueous environment communication between living organisms depends on solubility in water.Given all these factors it is not surprising that marine organisms are a wonderful source of biologically active natural products. It has taken half a century for this to be fully appreciated. In this time the means of collection have been developed so that marine diving, at least in shallow coastal waters, is relatively simple. Also, more sensitive biological tests are available and can be carried out on board ship. The result of all this is that there is an avalanche of new and biologically exciting marine natural products. However, there is one negative aspect to this work. It is that the compounds isolated are often available in minute amounts only.
Therefore, if the structure is complex, it is an arduous, and often impossible, task to isolate enough of the natural material for clinical trials. This is where synthetic chemistry can come to the help of the clinician. Marine natural products are often wonderful challenges to synthetic chemists. The present book by Dr. D.S. Bhakuni, a distinguished expert on natural products chemistry, [and Dr. D.S. Rawat] will serve as an excellent introduction to the scientific methods involved in marine natural products chemistry. It includes a description of the compounds and their biosynthesis. Of course, there can be no clinical discovery without prior and extensive biological testing so these procedures are also described in some detail. But before any clinical tests can be carried out, the compound must be isolated. Even if there is never enough for clinical testing, the isolation and determination of structure must take priority. All these aspects of marine natural products chemistry are treated with authority in this book. It is certain to become an internationally accepted and widely read volume on an important subject.
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I need this E-book to use a refferences to learn about marine natural product