Nanoparticulate Drug Delivery Systems

Pharmaceutical industry research culture is facing an uncertain future. Higher clinical development cost coupled with declining drug-discovery process and lower clinical success rates is decreasing the flow of new chemical entities in the research and development pipeline. Due to the advent of analytical techniques and capabilities to measure the particle sizes in nanometer ranges, particulate drug-delivery systems research anddevelopment has been moving from the micro- to the nanosize scale. Significant research interests are geared towards utilizing the techniques where the particles can be reduced almost to nanometer ranges, thus reducing the dose and reactive nature of the molecule. This can deliver the drug at the targeted sites.

The book presented herewith is an attempt to describe the research efforts being done in this direction by the global scientific community. Nanoparticulate drug-delivery systems are a challenging area, and there are pulsating changes happening almost every day. This is an attempt to cover the recent trends and emerging technologies in the area of nanoparticulate drug-delivery systems.

The first chapter covers a complete overview of the nanoparticulate drugdelivery system, covering wide applications and evaluation of the nanoparticulate drug-delivery system in various fields. Chapter 2 encompasses formulations of nanosuspensions for parenteral delivery. The third chapter covers the polymerbased nanoparticulate drug-delivery systems. Chapters 4 to 6 focus on nanofibers, nanocrystals, and lipid-based nanoparticulate drug-delivery systems, respectively. Chapters 7 to 10 discuss the engineering aspects and different techniques used for nanoparticulate drug-delivery systems, including nanoengineering, aerosol flow eactor, supercooled smectic nanoparticles, and metallic nanoparticles, respectively. Chapters 11 and 12 focus on biological requirements and the role of nanobiotechnology in the development of nanomedicines. Chapters 13 to 21 extensively cover the applications of nanoparticulate drug-delivery systems, including lipid nanoparticles for dermal applications; gene carriers for restenosis; ocular, central nervous system, gastrointestinal applications; adjuvant for vaccine development; and transdermal systems.

This book is equally relevant to academic, industrial, as well as scientists working in pharmaceutical drug delivery worldwide. The text is planned in such a way that each chapter represents an independent area of research and can be easily followed without referring to other chapters.

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