Autonomic Failure

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Autonomic Failure


Autonomic Failure
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Autonomic Failure


Autonomic Failure
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Author : Christopher J. Mathias
language : en
Publisher: OUP Oxford
Release Date : 2013-06-13

Autonomic Failure written by Christopher J. Mathias and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-13 with Medical categories.


This new edition makes diagnosis increasingly precise by fully evaluating the underlying anatomical and functional deficits, and continues to provide practitioners from a variety of fields with a rational guide to aid in the recognition and management of autonomic disorders.

Autonomic Nervous System


Autonomic Nervous System
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Author : Emily M. Garland
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-11-11

Autonomic Nervous System written by Emily M. Garland and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.


A 1925 report by Bradbury and Eggleston first described patients with extreme orthostatic hypotension and a low, steady heart rate. Evidence accumulated over the next two decades that patients with orthostatic hypotension include those with pure autonomic failure (PAF), characterized by isolated peripheral autonomic dysfunction and decreased norepinephrine synthesis; multiple system atrophy (MSA) with symptoms of a central Parkinson-like syndrome and normal resting plasma norepinephrine; and Parkinson’s disease (PD), with lesions in postganglionic noradrenergic neurons and signs of autonomic dysfunction. All three disorders are classified as α-synucleinopathies. Insoluble deposits of α-synuclein are found in glia in MSA, whereas they take the form of neuronal cytoplasmic inclusions called Lewy bodies in PAF and PD. The exact relationship between α-synuclein deposits and the pathology remains undetermined. PAF occurs sporadically, and progresses slowly with a relatively good prognosis. However, it has been proposed that some cases of PAF may develop a central neurodegenerative disorder. Differentiation between PAF, MSA, and PD with autonomic failure can be facilitated by a number of biochemical and functional tests and by imaging studies. Cardiac sympathetic innervation is generally intact in MSA but decreased or absent in Parkinson’s disease with autonomic failure and PAF. Treatment of PAF is directed at relieving symptoms with nonpharmacological interventions and with medications producing volume expansion and vasoconstriction. Future studies should focus on determining the factors that lead to central rather than solely peripheral neurodegeneration.

Autonomic Nervous System


Autonomic Nervous System
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Author : Srikanth Muppidi
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-11-11

Autonomic Nervous System written by Srikanth Muppidi and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.


Autoimmune autonomic ganglionopathy is a syndrome of panautonomic failure caused by antibodies to ganglionic acetylcholine receptors. The clinical syndrome is characterized by significant postural hypotension, diffuse cholinergic and adrenergic impairment, gastrointestinal dysmotility, urinary retention, and pupillary dysfunction. While acute to subacute onset of disease is commonly seen, chronic, slowly progressive variants have been described. Serological testing for ganglionic acetylcholine receptor antibodies helps confirm the diagnosis. These antibodies cause a similar phenotype of autonomic failure in animal models indicating that an antibody-mediated functional impairment of ganglionic transmission is the underlying etiology. Decrease in antibody levels correlates with clinical improvement. Patients may respond to immunomodulatory therapies such as prednisone, intravenous immunoglobulin, plasma exchange, and oral immunosuppressants. A combination treatment is often required as well as symptomatic therapy.

Clinical Autonomic Dysfunction


Clinical Autonomic Dysfunction
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Author : Joseph Colombo
language : en
Publisher: Springer
Release Date : 2014-09-22

Clinical Autonomic Dysfunction written by Joseph Colombo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-22 with Medical categories.


This book presents the concepts underlying the measurement of parasympathetic and sympathetic (P&S) activity in the autonomic nervous system and the application of these measurements in the development of therapeutic guidelines for treating dysfunctions in these processes. It provides an overview of the anatomy, physiology, and biochemistry of the autonomic nervous system; details general clinical applications of P&S monitoring that are independent of specialty or disease; presents the pathophysiology of P&S dysfunction in specific disorders, expected test results, therapeutic options, and expected outcomes; and includes case studies and longitudinal studies that demonstrate the major concepts for the common diseases for which P&S monitoring is recommended. Clinical Autonomic Dysfunction enables clinicians to improve patient outcomes by identifying and treating clinical problems related to autonomic nervous system disorders.

Primer On The Autonomic Nervous System


Primer On The Autonomic Nervous System
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Author : David Robertson
language : en
Publisher: Academic Press
Release Date : 2011-11-03

Primer On The Autonomic Nervous System written by David Robertson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-03 with Medical categories.


The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist’s bookshelf! Greatly amplified and updated from previous edition including the latest developments in the field of autonomic cardiovascular regulation and neuroscience Provides key information about all aspects of autonomic physiology and pathology Discusses stress and how its effects on the body are mediated Compiles contributions by over 140 experts on the autonomic nervous system

Neurological Rehabilitation


Neurological Rehabilitation
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Author : Christopher J. Mathias
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-01-10

Neurological Rehabilitation written by Christopher J. Mathias and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-10 with Medical categories.


The autonomic nervous system (ANS), through its central connections and efferent pathways, innervates every organ in the body, influences their function, and is also involved in a number of integrative systems such as those concerned with maintenance of arterial blood pressure, organ perfusion, and body temperature. Responsive functioning of the ANS is thus needed in a variety of situations; it contributes to well being, and is essential for survival. Autonomic dysfunction may occur in a number of neurological diseases and may complicate various medical disorders. This chapter will provide an outline of the scientific principles, followed by classification of autonomic disorders, an outline of the autonomic investigations, brief accounts of some of the key disorders and the pathophysiological mechanisms involved, and discussion of treatment, emphasizing the importance of non-pharmacological methods and, in particular, the role of autonomic neurorehabilitation.

Clinical Autonomic Failure


Clinical Autonomic Failure
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Author : Otto Appenzeller
language : en
Publisher: Elsevier Publishing Company
Release Date : 1986

Clinical Autonomic Failure written by Otto Appenzeller and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Autonomic Nervous System Diseases categories.