Circulating Tumor Cells

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Circulating Tumor Cells


Circulating Tumor Cells
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Circulating Tumor Cells In Breast Cancer Metastatic Disease


Circulating Tumor Cells In Breast Cancer Metastatic Disease
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Author : Roberto Piñeiro
language : en
Publisher: Springer Nature
Release Date : 2020

Circulating Tumor Cells In Breast Cancer Metastatic Disease written by Roberto Piñeiro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Biomedical engineering categories.


This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.

Circulating Tumor Cells


Circulating Tumor Cells
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Author : Richard J. Cote
language : en
Publisher: Springer
Release Date : 2016-02-03

Circulating Tumor Cells written by Richard J. Cote and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-03 with Medical categories.


This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers. CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive “liquid biopsy” procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development. In recent years there has been rapid growth and worldwide developments on CTCs, which span both the basic sciences and biomedical engineering fields.

Circulating Tumor Cells


Circulating Tumor Cells
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Author : Catherine Alix-Panabieres
language : en
Publisher: MDPI
Release Date : 2020-04-03

Circulating Tumor Cells written by Catherine Alix-Panabieres and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-03 with Science categories.


The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.

Circulating Tumor Cells


Circulating Tumor Cells
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Author : Z. Hugh Fan
language : en
Publisher: John Wiley & Sons
Release Date : 2016-03-25

Circulating Tumor Cells written by Z. Hugh Fan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-25 with Science categories.


Introduces the reader to Circulating Tumor Cells (CTCs), their isolation method and analysis, and commercially available platforms Presents the historical perspective and the overview of the field of circulating tumor cells (CTCs) Discusses the state-of-art methods for CTC isolation, ranging from the macro- to micro-scale, from positive concentration to negative depletion, and from biological-property-enabled to physical-property-based approaches Details commercially available CTC platforms Describes post-isolation analysis and clinical translation Provides a glossary of scientific terms related to CTCs

Atlas Of Liquid Biopsy


Atlas Of Liquid Biopsy
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Author : Ludmilla Thomé Domingos Chinen
language : en
Publisher: Springer Nature
Release Date : 2021-05-31

Atlas Of Liquid Biopsy written by Ludmilla Thomé Domingos Chinen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-31 with Medical categories.


This book provides a wealth of images and extensive information on circulating tumor cells (CTCs) and other cells usually observed in blood from patients with cancer, such as giant macrophages, and circulating tumor microemboli (CTM). The field of “liquid biopsy” began with the analysis of CTCs in the early 2000s. In the beginning, molecular techniques were developed to detect these cells in the blood. However, it has since become clear that CTCs initially require a cytopathological analysis to be detected without false positive and negative results. After detection, molecular analysis can be subsequently performed. Cancer is an important cause of mortality, especially when detected in late stages. Even with all the advances that have been made in its treatment, cancer is still challenging, as many patients do not respond to any therapy. Many health agencies have considered early diagnosis as a feasible tool. In this context, it is of the utmost importance to know the morphology and characteristics of CTCs to determine a correct diagnosis. Currently much of the scientific community is committed to expanding our knowledge of CTCs, and this work makes a valuable contribution, presenting hundreds of cell images from patients with various types of cancer, in many different stages of disease, and after receiving various treatments. The Atlas of Liquid Biopsy: Circulating Tumor Cells and Other Rare Cells in Cancer Patients’ Blood is an essential reference guide for all physicians, biologists, biomedics, and professionals working at clinical and research laboratories, hospitals and research centers.

Isolation And Molecular Characterization Of Circulating Tumor Cells


Isolation And Molecular Characterization Of Circulating Tumor Cells
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Author : Mark Jesus M. Magbanua
language : en
Publisher: Springer
Release Date : 2017-05-29

Isolation And Molecular Characterization Of Circulating Tumor Cells written by Mark Jesus M. Magbanua and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-29 with Medical categories.


Numerous studies have shown that elevated levels of circulating tumor cells (CTCs) in blood of cancer patients are associated with poor response to treatment and inferior survival probabilities. Despite this clinical significance, the molecular biology of CTCs remains poorly understood. The paucity in molecular information can be attributed to the tremendous technical challenges involved in isolating these extremely rare cells. Recent technological advancements in rare-cell technology, however, have allowed for the reliable enrichment and isolation of CTCs. Consequently, the use of recently developed molecular approaches —e.g., multiplexed QPCR, microarray, and next generation sequencing analyses— to profile CTCs have provided novel insights into the molecular makeup of these tumor cells. This book discusses approaches for enrichment and isolation of CTCs as well as recent advances in comprehensive molecular profiling of CTCs using cutting-edge omics technology.

Therapeutic Targeting Of Circulating Tumor Cells


Therapeutic Targeting Of Circulating Tumor Cells
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Author : Michael R. King
language : en
Publisher: Frontiers E-books
Release Date :

Therapeutic Targeting Of Circulating Tumor Cells written by Michael R. King and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.


There has been increased interest in circulating tumor cells (CTC), as a diagnostic readout of disease progression, and a tool for personalized medicine. The next generation of therapy for metastatic cancer may well involve neutralizing CTC as a means to prevent metastasis. In this topic we focus on recent research exploring this concept.