Clinical And Translational Science

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Clinical And Translational Science


Clinical And Translational Science
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Clinical And Translational Science


Clinical And Translational Science
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Author : David Robertson
language : en
Publisher: Academic Press
Release Date : 2016-11-25

Clinical And Translational Science written by David Robertson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-25 with Science categories.


Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Clinical And Translational Science


Clinical And Translational Science
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Author : David Robertson
language : en
Publisher: Academic Press
Release Date : 2009-03-02

Clinical And Translational Science written by David Robertson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-02 with Medical categories.


Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science. Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications Contributions from international leaders provide insight into background and future understanding for clinical and translational science Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

The Ctsa Program At Nih


The Ctsa Program At Nih
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2013-10-09

The Ctsa Program At Nih written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-09 with Medical categories.


In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

Clinical And Translational Perspectives On Wilson Disease


Clinical And Translational Perspectives On Wilson Disease
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Author : Nanda Kerkar
language : en
Publisher: Academic Press
Release Date : 2018-09-18

Clinical And Translational Perspectives On Wilson Disease written by Nanda Kerkar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-18 with Medical categories.


Clinical and Translational Perspectives on Wilson Disease brings together the genetics, cell and structural biology of Wilson Disease into one contemporary, easy to navigate handbook. Created to meet the diverse needs of the clinical and research communities surrounding Wilson Disease, this reference provides a worldwide approach that is concise and translational. Specifically, it provides a basis for clinicians to appreciate ‘basic science’ aspects of Wilson disease, presenting a guide for researchers to understand the clinical disorder on which their research is focused and fostering constructive dialogue and progress for this puzzling disorder. Delivers numerous, succinct, expert chapters with summaries designed for quick reference Includes a 'How-to appendix' for diagnosis and management tips Contains access to a companion website with a self-help teaching module, links to key resources, and an extended reference list

Broadly Engaged Team Science In Clinical And Translational Research


Broadly Engaged Team Science In Clinical And Translational Research
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Author : Debra J. Lerner
language : en
Publisher: Springer Nature
Release Date : 2022

Broadly Engaged Team Science In Clinical And Translational Research written by Debra J. Lerner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Biology categories.


Despite the large U.S. investment in health science, and the vast and growing body of peer-reviewed research findings it has produced, a compelling body of evidence suggests that research too often has been slow, inefficient, and fallen short of desired impacts on health. A key question is how research might be changed to be more innovative, less wasteful, and more responsive to unmet health needs. One emerging response within clinical and translational science is to advance an approach that attempts to close the gap between research scientists and key stakeholders; the individuals and groups responsible for or affected by health-related decisions. Broadly engaged team science promises to support this aim by transforming the gold standard, multi-disciplinary team science, to include key stakeholders in activities across the research spectrum. These new roles and responsibilities range from generating research questions to implementing research projects, to aiding in the translation of discoveries from the laboratory to the community. A transition to broadly engaged team science reflects the idea that inclusivity and a diversity of perspectives are necessary to achieving progress in addressing complex health issues while representing a new benchmark for ethical research practice. This is one of the first collections of papers describing how clinical and translational science researchers are defining and implementing new research practices, and the successes and challenges involved. This book represents a first and critical step towards organizing knowledge of broadly engaged team science and advancing the development of evidence-based practices. Written in an accessible style, this book is intended to highlight the breadth of broadly engaged team science within one community, motivate researchers and stakeholders to build inclusive teams, bring rigor to often informal stakeholder engagement research practices and encourage people to think more broadly about the development of scientific knowledge. It includes examples of multi-disciplinary, broadly engaged team science projects, the perspectives of academic leaders about the changes needed to encourage scientists to conduct broadly engaged team science, and a resource directory.

Pharmaceutical Medicine And Translational Clinical Research


Pharmaceutical Medicine And Translational Clinical Research
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Author : Divya Vohora
language : en
Publisher: Academic Press
Release Date : 2017-11-14

Pharmaceutical Medicine And Translational Clinical Research written by Divya Vohora and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-14 with Medical categories.


Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features. As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource. Includes detailed coverage of current trends and key topics in pharmaceutical medicine, including biosimilars, biobetters, super generics, and Provides a comprehensive look at current and important aspects of the science and regulation of drug and biologics discovery

Pediatric Traumatic Brain Injury


Pediatric Traumatic Brain Injury
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Author : Vicki Anderson
language : en
Publisher: Cambridge University Press
Release Date : 2010-02-04

Pediatric Traumatic Brain Injury written by Vicki Anderson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-04 with Family & Relationships categories.


"This book, New Frontiers in Pediatric Traumatic Brain Injury, aims to evaluate what we have learned about TBI in childhood to date and, perhaps more importantly to articulate the challenges we face and how we should go forward in the future"--Provided by publisher.