Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer

Download Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer book now. This site is like a library, Use search box in the widget to get ebook that you want.

If the content Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer not Found or Blank , you must refresh this page manually.

Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer


Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer
DOWNLOAD
READ ONLINE

Download Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer PDF/ePub, Mobi eBooks by Click Download or Read Online button. Instant access to millions of titles from Our Library and it’s FREE to try! All books are in clear copy here, and all files are secure so don't worry about it.



Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer


Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer
DOWNLOAD
READ ONLINE


Author : Michail Ignatiadis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-04-23

Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer written by Michail Ignatiadis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-23 with Medical categories.


This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

Circulating Tumor Cells In Breast Cancer Metastatic Disease


Circulating Tumor Cells In Breast Cancer Metastatic Disease
DOWNLOAD
READ ONLINE


Author : Roberto Piñeiro
language : en
Publisher: Springer Nature
Release Date : 2020

Circulating Tumor Cells In Breast Cancer Metastatic Disease written by Roberto Piñeiro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Biomedical engineering categories.


This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.

Multi Modality Plasma Based Detection Of Minimal Residual Disease In Triple Negative Breast Cancer


Multi Modality Plasma Based Detection Of Minimal Residual Disease In Triple Negative Breast Cancer
DOWNLOAD
READ ONLINE


Author : Yu-Hsiang Chen
language : en
Publisher:
Release Date : 2019

Multi Modality Plasma Based Detection Of Minimal Residual Disease In Triple Negative Breast Cancer written by Yu-Hsiang Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.


Triple-negative breast cancers (TNBCs) are pathologically defined by the absence of estrogen, progesterone, and HER2 receptors. Compared to other breast cancers, TNBC has a relatively high mortality. In addition, TNBC patients are more likely to relapse in the first few years after treatment, and experiencing a shorter median time from recurrence to death. Detecting the presence of tumor in patients who are technically "disease-free" after neoadjuvant chemotherapy and surgery as early as possible might be able to predict recurrence of patients, and then provide timely intervention for additional therapy. To this end, I applied the analysis of "liquid biopsies" for early detection of minimal residual disease (MRD) on early-stage TNBC patients using next-generation sequencing. For the first part of this study, I focused on detecting circulating tumor DNA (ctDNA) from TNBC patients after neoadjuvant chemotherapy and surgery. First, patient-specific somatic mutations were identified by sequencing primary tumors. From these data, 82% of the patients had at least one TP53 mutation, followed by 16% of the patients having at least one PIK3CA mutation. Next, I sequenced matched plasma samples collected after surgery to identify ctDNA with the same mutations. I observed that by detecting corresponding ctDNA I was able to predict rapid recurrence, but not distant recurrence. To increase the sensitivity of MRD detection, in the second part I developed a strategy to co-detect ctDNA along with circulating tumor RNA (ctRNA). An advantage of ctRNA is its active release into the circulation from living cancer cells. Preliminary data showed that more mutant molecules were identified after incorporating ctRNA with ctDNA detection in a metastatic breast cancer setting. A validation study in early-stage TNBC is in progress. In summary, my study suggests that co-detection of ctDNA and ctRNA could be a potential solution for the early detection of disease recurrence

Biological Mechanisms Of Minimal Residual Disease And Systemic Cancer


Biological Mechanisms Of Minimal Residual Disease And Systemic Cancer
DOWNLOAD
READ ONLINE


Author : Julio A. Aguirre-Ghiso
language : en
Publisher: Springer
Release Date : 2018-11-08

Biological Mechanisms Of Minimal Residual Disease And Systemic Cancer written by Julio A. Aguirre-Ghiso and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-08 with Medical categories.


This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.

Minimal Residual Disease In Melanoma


Minimal Residual Disease In Melanoma
DOWNLOAD
READ ONLINE


Author : U. Reinhold
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Minimal Residual Disease In Melanoma written by U. Reinhold and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


Knowledge about diagnostic procedures in melanoma has in creased rapidly within the past few years. Single tumor cells have been identified in normal tissue such as sentinel lymph nodes, as well as in bone marrow, peripheral blood, and other bodily fluids and cells, by molecular technologies. The introduction of polymerase chain reaction-based methods can be regarded as a prototype of this dramatic development towards molecular approaches in new diagnostic procedures. This fact opens up the possibility of clinical use in patients and of influencing treatment strategies. Considerable discrepancies have been described, how ever, in the success rates of these new techniques for the detec tion of minimal residual disease in cancer patients. Despite fav orable results reported by different groups of investigators, it will take several years to define the clinical and pathophysiological relevance of new diagnostic procedures. The 1st International Symposium "Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance of Microme tastases", held in September 1999 in Homburg/Saar, Germany, fo cused on recent developments in this particular area of cancer re search. The purpose of the meeting was to stimulate discussion and exchange of new data and ideas by renowned international scientists. The aim of this volume is to summarize major topics of basic research and clinical investigations presented by invited experts in this fascinating but still. controversial field of melanoma re search.

Tumor Liquid Biopsies


Tumor Liquid Biopsies
DOWNLOAD
READ ONLINE


Author : Florence Schaffner
language : en
Publisher: Springer Nature
Release Date : 2019-10-11

Tumor Liquid Biopsies written by Florence Schaffner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-11 with Medical categories.


This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

Tumor Markers


Tumor Markers
DOWNLOAD
READ ONLINE


Author : Eleftherios P. Diamandis
language : en
Publisher: Amer. Assoc. for Clinical Chemistry
Release Date : 2002

Tumor Markers written by Eleftherios P. Diamandis and has been published by Amer. Assoc. for Clinical Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.